Police said six warrants had been executed and 11 people, aged between 19 and 38, had been arrested over the past month.
The alleged offences include sexual activity with a child, attempted indecent assault, inciting a child into prostitution, abduction and rape.
Greater Manchester Police said the 11 had all been bailed.
The arrests followed intervention work in the Longsight area, a spokesperson for the force said.
They were part of Project Phoenix, which is made up of police, children’s services, health services, and children’s charity Barnardo’s and covers the Salford and Manchester areas.
“Eleven people have been arrested as part of a crackdown on child sexual exploitation in south Manchester”